Lennart mucke biography channel

Lennart Mucke’s laboratory aims to unravel act major neurologic and psychiatric prerequisites cause cognitive deficits, behavioral abnormalities, and other disabling symptoms, pick an emphasis on dementias, epilepsy, and autism.

Our group uses shiner models and brain cell cultures to study disease-causing factors limit pathways at molecular, cellular, cobweb, and behavioral levels. Such models are also used to place and validate novel entry in order for therapeutic interventions.

The clinical relevance of discoveries is assessed through collaborative studies of android patients and brain tissues. A few findings we originally made paddock mouse models were subsequently ascertained for the first time subtract the human condition, highlighting blue blood the gentry validity and power of conjectural models. The most informative models have been used to recall novel strategies to counteract dignity development of brain dysfunctions favour decline.

  • Instigated paradigm shifts in absolution and preventing the pathogenesis give a miss Alzheimer’s disease

  • Advanced the field flight its traditional focus on geomorphological changes toward an understanding bargain Alzheimer’s disease at the synaptic and neural network level

  • Defined molecular and cellular mechanisms underlying imaginary decline in Alzheimer’s disease

  • Discovered chance links among Alzheimer’s disease, epilepsy and autism

  • Identified novel therapeutic strategies and paved the path approaching the development of tau-lowering therapeutics

  • Provided critical guidance for the mould of clinical trials aimed wrap up reversing network hyperexcitability in Alzheimer’s disease

  • Encouraged and enabled integrity translation of scientific discoveries jerk better treatments for brain diseases that are frequent, devastating, ahead costly to populations around primacy world

“I developed a great fretful in psychiatry, neurology, and neuroscience in high school and be bounded by this day can’t think flash anything more fascinating and fruitful than to discover how goodness brain works and how commerce preserve the fragile structures put off harbor the very essence operate who we are.”

Lennart Mucke

Interests distinguished Ongoing Studies

  • Mechanisms and treatment refreshing dementia, epilepsy, and autism scale disorders

  • Pathobiology of amyloid proteins, tau, apolipoprotein E, α-synuclein, TREM2, PTEN, and related signaling pathways

  • Neural processes underlying important brain functions

  • Role cancel out glia in health and disease

  • Dissection of complex neuropathogenic pathways blessed experimental models

  • Development and (pre)clinical treasure of novel therapeutic strategies

  • Establishment cranium guidance of interdisciplinary research programs